DR ANTHONY MELVIN CRASTO,WorldDrugTracker, helping millions, A 90 % paralysed man in action for you, I am suffering from transverse mylitis and bound to a wheel chair, This will not stop me
DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai), INDIA, worlddrugtracker, 25Yrs Exp. in the feld of Organic Chemistry,Working for GLENMARK GENERICS at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational contributio

Saturday, 31 August 2013

Hope In A Pill- A crop of small-molecule drugs in development could double the treatment options for people with multiple sclerosis in coming years

PROMISING PIPELINE Numerous small-molecule drugs are in late-stage development to treat MS
New Crop: Research into multiple sclerosis has yielded a host of drug candidates.EMD Serono
NEW CROP Research into multiple sclerosis has yielded a host of drug candidates.
For people with MS, oral drugs that could address both the immune and neurological components of the disease represent a beacon of hope. “If I could take a pill, I almost wouldn’t mind having this disease,” Sommers says. Mentally gearing up for the weekly shot and the possible side effects takes its toll over the years, he says. Putting aside the syringes “would make it a lot more tolerable,” he says. “I am very excited that there might be some oral drugs down the road.”

Tuesday, 20 August 2013



This was at ankleshwar, gujarat, India, Started with severe pain in back at 7 in morning , sweating , increase in bp, rushed from hotel in ankleshwar to glenmark factory , sat, had water, one of the leg, right collapsed with loss of sensation. deepak helped me

called up shobha and told her

doctors thought sugar deficiency, so they gave me icecream. francis was along

I was shifted to bharuch under intensive care since my bp was high.

waited there ...............

full night with staff , francis along and bp recorder in one arm, getting pain. not allowed to talk on phone. no doctor rushing .  no attention.............no urgency.....................only a resident doctor. next morning on 6th dec 2006 a ct scan . no result..... wait ..................................................wait . ........................................................................................................................... time running out;;;;;;;;;;;;; told flight, told chopper,may be gujarat elections. choppers not allowed ................nothing arrived..............wait........................wait.................................................

finally ...............................in   evening put in an ambulance for mumbai,,,,,,,,,,,,, ct scan  of brain no result again
second day gone, no medicine
admitted to holy family bandra india in the night. this time left leg collapsed ..................

Sunday, 4 August 2013

Acute transverse mylitis at medify website

read all about acute transverse mylitis at


see this on medify

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Chhatrapati Shahuji Maharaj Medical University
Baylor College of Medicine
University of Toronto

Transverse Myelitis PDFs and free access published articles

Transverse Myelitis PDFs and free access published articles

Transverse Myelitis PDFs and free access published articles 

Transverse myelitis is a neurological disorder caused by inflammation across both sides of one level, or segment, of the spinal cord. The segment of the spinal cord at which the damage occurs determines which parts of the body are affected.
Recurrent Myelitis Associated With Hepatitis C Infection
Neuro MRI Ordering Guide
General Information Regarding MS
NMO-IgG predicts the outcome of recurrent optic neuritis
NMO-IgG Rose-Innes_article1.pdf
Aquaporin-4 Antibodies in Neuromyelitis Optica and Longitudinally Extensive Transverse Myelitis
Patrick Waters, PhD; Sven Jarius, MD; Edward Littleton, MBBS, DPhil; Maria Isabel Leite, MD etal
Aquaporin-4 Antibodies in Neuromyelitis.pdf
Transverse myelitis – Case study
Transverse myelitis.pdf
Diagnosis of Transverse Myelitis: An Evaluation of the factors leading to Spinal Dysfunction
Including a Review of one patients’ experience
Diagnosis of Transverse Myelitis.pdf
Imaging Sciences Interesting Cases
Jacinto Camarena III, MD
50 Free scholarly articles on Transverse myelitis
  1. Idiopathic transverse myelitis and neuromyelitis optica: clinical profiles, pathophysiology and therapeutic choices.
  2. Urinary retention in immunocompetent patient: acute transverse myelitis.
  3. Acute transverse myelitis in Buenos Aires, Argentina. A retrospective cohort study of 8 years follow up.
  4. Rhabdomyolysis, acute kidney injury and transverse myelitis due to naive heroin exposure.
  5. Longitudinally extensive transverse myelitis: a catastrophic presentation of a flare-up of systemic lupus erythematosus.
  6. Primary HIV infection with acute transverse myelitis.
  7. H1N1 vaccine-related acute transverse myelitis.
  8. Acute transverse myelitis following vaccination against H1N1 influenza: a case report.
  9. Acute transverse myelitis and acute motor axonal neuropathy developed after vaccinations against seasonal and 2009 A/H1N1 influenza.
  10. Optical coherence tomography evaluation of retinal nerve fiber layer in longitudinally extensive transverse myelitis.
  11. Clinical analysis of 6 cases of systemic lupus erythematosus complicated by transverse myelitis.
  12. Mycobacteria infection in incomplete transverse myelitis is refractory to steroids: a pilot study.
  13. Acute transverse myelitis associated with dengue viral infection.
  14. Idiopathic acute transverse myelitis in children: an analysis and discussion of MRI findings.
  15. Longitudinally extensive transverse myelitis following vaccination with nasal attenuated novel influenza A(H1N1) vaccine.
  16. Transverse myelitis associated with chronic viral hepatitis C.
  17. High-level cervical spinal cord stimulation used to treat intractable pain arising from transverse myelitis caused by schistosomiasis.
  18. Acute transverse myelitis: treatment of pain.
  19. Transverse myelitis associated to HCV infection.
  20. Acute transverse myelitis: a clinical review and algorithm for diagnostic intervention.
  21. Priapism in infantile transverse myelitis.
  22. Transverse myelitis spectrum disorders.
  23. Transverse myelitis as a presenting feature of late onset systemic lupus erythematosus.
  24. Acute transverse myelitis and Guillain-Barre overlap syndrome following influenza infection.
  25. Diffusion tensor imaging in idiopathic acute transverse myelitis.
  26. Aquaporin-4 antibodies in neuromyelitis optica and longitudinally extensive transverse myelitis.
  27. Transverse myelitis due to human herpesvirus 6.
  28. Subacute transverse myelitis with Lyme profile dissociation.
  29. Transverse myelitis associated with systemic lupus erythematosus.
  30. Idiopathic recurrent transverse myelitis with syringomyelia: a case report.
  31. Acute transverse myelitis at the conus medullaris level after rabies vaccination in a patient with Behçet’s disease.
  32. Transverse myelitis in a patient with severe lupus nephritis: a case report.
  33. Transverse myelitis in 2 patients with Bartonella henselae infection (cat scratch disease).
  34. Transverse myelitis caused by varicella zoster: case reports.
  35. Transverse myelitis in systemic lupus erythematosus.
  36. Acute transverse myelitis following typhoid vaccination.
  37. Transverse myelitis following spinal anesthesia.
  38. Neuromyelitis optica IgG status in acute partial transverse myelitis.
  39. Neurosyphilis manifesting as spinal transverse myelitis.
  40. Etanercept induced multiple sclerosis and transverse myelitis.
  41. Acute transverse myelitis following hepatitis E virus infection.
  42. Transverse myelitis due to trypanosomiasis in a middle aged Tanzanian man.
  43. Rapid recovery from acute transverse myelitis in an elite female swimmer.
  44. IL-6 induces regionally selective spinal cord injury in patients with the neuroinflammatory disorder transverse myelitis. 
  45. Acute transverse myelitis and hepatitis C virus.
  46. Transverse myelitis and chronic urticaria in systemic lupus erythematosus. Case report.
  47. Primary biliary cirrhosis complicated by transverse myelitis in a patient without Sjögren’s syndrome.
  48. Transverse myelitis in immunocompetent children.
  49. Early-onset acute transverse myelitis following hepatitis B vaccination and respiratory infection: case report.
  50. Acute transverse myelitis: important role of biology in diagnosis.

ME and transverse mylitis

Today , I take this opportunity to update any one needing information on transverse myletis, one in a million ailment, which I am going through myself , will give self support to any one approaching on mail, person or phone
call me in India, +91 9323115463
Paralysis head to toe, from DEC 2007 TILL TODAY AUG 2013. poor recovery, hands ok , head ok and miraculously all organs ok, diabetic and medical attention needed for that
on a wheel chair
bowel zero, all sensation zero below neck
plus points
motivation unmatched, sleep 5 hrs, office work 7 hrs, computer or ipad 6 hrs

special care
control blood thickness, avoid vein thrombosis, stretch limbs physically using help,try more exercises on bed, avoid fever, try antibiotics quickly in iv format, keep tight control on diabetes if any
sixth sense extraordinary, knowledge grasp 1000 times more, motivation high to live and focussed on living only, no much desires except childrens happiness. television, news , sports are hobbies

Acute transverse mylitis treatment


Intravenous steroid treatment is the first line of therapy often used in acute TM. Corticosteroids have multiple mechanisms of action including anti-inflammatory activity, immunosuppressive properties, and antiproliferative actions. Though there is no randomized double-blind placebo-controlled study that supports this approach, evidence from related disorders and clinical experience support this treatment. At the Johns Hopkins TM Center, the standard of care includes intravenous methylprednisolone (1000 mg) or dexamethasone (200 mg) for 3 to 5 days unless there are compelling reasons to avoid this therapy. The decision to offer continued steroids or to add a new treatment is often based on the clinical course and MRI appearance at the end of 5 days of steroids.
PLEX is often initiated in moderate to severe TM (i.e., inability to walk, markedly impaired autonomic function, and sensory loss in the lower extremities) in individuals who show little clinical improvement after instituting 5 to 7 days of intravenous steroids, but may also be initiated at first presentation. PLEX is believed to work in autoimmune CNS diseases through the removal of specific or nonspecific soluble factors likely to mediate, be responsible for, or contribute to inflammatory-mediated target organ damage. PLEX has been shown to be effective in adults with TM and other inflammatory disorders of the CNS.
If there is continued progression despite intravenous steroid therapy and PLEX, pulse dose intravenous cyclophosphamide (800–1000 mg/m2) is considered. Cyclophosphamide is known to have immunosuppressive properties. From the Johns Hopkins TM Center experience, it has been reported that PLEX provided an added benefit to steroids in patients who were not at a disability level of ASIA A and who did not have a history of autoimmune disease. For those who were classified at a disability level of ASIA A at their nadir, they showed a significant benefit when given combination therapy with steroids, PLEX and IV cyclophosphamide. Cyclophosphamide should be administered under the supervision of an experienced oncology team, and caregivers should monitor the patient carefully for hemorrhagic cystitis and cytopenias.
Chronic immunomodulatory therapy should be considered for recurrent TM. The ideal treatment regimen is not known and it is important for your neurologist to consult with a specialist who has significant experience in treating these rare, recurrent neuroimmunologic disorders.

What is Transverse Myelitis

Transverse myelitis is a rare neurological disorder of the spine that is caused by inflammation across the spinal cord.
Inflammation is usually a protective response, which generally includes swelling, pain, heat, and redness. However, in the case of transverse myelitis, the inflammatory response causes damage to the spinal cord, resulting in varying degrees of weakness, sensory symptoms, and autonomic dysfunction. The symptoms and dysfunction that occurs is usually dependent on the level of the spine where the inflammation is located.
Transverse myelitis is believed to be linked to the immune system. It is possible that the immune system is attacking the body’s own spinal cord. Unfortunately, the immune system can attack rapidly without warning, resulting in devastating impairment.
Transverse myelitis generally occurs on a single occasion. However, a small number of individuals may experience a recurrence.
Transverse myelitis is sometimes associated with other diseases, such as systemic autoimmune diseases. Systematic immune diseases include diseases such as systemic lupus erythematosis and sarcoidosis.

What do the different transverse myelitis terms mean?

There are quite a few different ways that people (and physicians) refer to transverse myelitis. Transverse myelitis has been referred to as a disorder, disease, condition, and syndrome.
Below is an explanation of the various terms.
    • What is Myelitis?: Indicates inflammation of the spinal cord.
    • What does Transverse mean?: Indicates that the inflammation is positioned across the width of the spinal cord.
    • What is Transverse Myelitis?: Spinal Cord inflammation that is positioned across the width of the spinal cord.
    • What is Acute Transverse Myelitis?: Indicates an acute (rapid onset) of spinal cord inflammation that is positioned across the width of the spinal cord.
    • What is Partial Transverse Myelitis?: Indicates spinal cord inflammation that is positioned across partial width of the spinal cord.
    • What is Acute Partial Transverse Myelitis?: Indicates an acute (rapid onset)of spinal cord inflammation that is positioned across partial width of the spinal cord.
    • Myelopathy: A term used to refer to any disorder of the spinal cord (including transverse myelitis).

What’s actually happening in the spinal cord?

Transverse myelitis affects the grey and white matter of the spinal cord. It can affect the entire thickness of the spinal cord.
The damage to the spinal cord can result in a lost or fuzzy signal between the brain and parts of the body. Therefore, symptoms of transverse myelitis are highly dependent on the location and severity of the spinal cord damage.
The following list outlines which section of the spine relays signals to which parts of the body:
      • cervical (neck) nerves: relay signals to neck, arms, hands, and breathing muscles
      • thoracic (upper back) nerves: relay signals to torso and arms.
      • lumbar (mid-back) nerves: relay signals to hips and legs.
      • sacral nerves: relay signals to groin, toes, and legs.
Generally, damage at one segment of the spinal accord will affect functions at that segment and the segments located below it.

How common is Transverse Myelitis?

Transverse myelitis is a rare disorder. Approximately one to five new cases per million people per year are diagnosed.
Transverse myelitis can affect all persons, regardless of gender, age, or race. However, it most commonly affects individuals between the ages of 10 and 39.

How severe is Transverse Myelitis?

The severity of transverse myelitis is highly dependent on the extent of the inflammation of the spinal cord. The severity is also impacted by the level of the spinal cord that is affected by the inflammation. Typically, the higher the spinal cord is affected, the more severe the impairment. For example, inflammation at the C5 level will generally result in more severe impairment than inflammation at the T1 level.\